STX-721   Click here for help

GtoPdb Ligand ID: 13004

Synonyms: STX721
Compound class: Synthetic organic
Comment: STX-721 is an oral, covalent and 'wild-type-sparing' EGFR inhibitor with selectivity for ex20ins (exon 20 insertion) mutatant receptors which are associated with resistance to commonly used EGFR inhibitors such as gefitinib and erlotinib. Targeting the mutated receptor is predicted to reduce skin and gut toxicities that are associated with wild-type EGFR inhibition. This chemical structure was obtained via Drug Hunter, as one of the 'first disclosure' novel small molecules revealed at the ACS meeting in August 2023.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 98.3
Molecular weight 587.11
XLogP 2.25
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C[C@@]1(CCCN1C(=O)/C=C/CN(C)C)C#CC2=C(C=CN=C2)C3=C(C4=C(CCNC4=O)N3)NC5=C(C(=CC=C5)Cl)OC
Isomeric SMILES C[C@@]1(CCCN1C(=O)/C=C/CN(C)C)C#CC2=C(C=CN=C2)C3=C(C4=C(CCNC4=O)N3)NC5=CC=CC(=C5OC)Cl
InChI InChI=1S/C32H35ClN6O3/c1-32(14-7-19-39(32)26(40)10-6-18-38(2)3)15-11-21-20-34-16-12-22(21)28-29(27-24(36-28)13-17-35-31(27)41)37-25-9-5-8-23(33)30(25)42-4/h5-6,8-10,12,16,20,36-37H,7,13-14,17-19H2,1-4H3,(H,35,41)/b10-6+/t32-/m1/s1
InChI Key UMSJPISUMQOUKS-LMZGTLAXSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
3-(3-chloro-2-methoxyanilino)-2-[3-[2-[(2R)-1-[(E)-4-(dimethylamino)but-2-enoyl]-2-methylpyrrolidin-2-yl]ethynyl]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
Synonyms Click here for help
STX721
Database Links Click here for help
GtoPdb PubChem SID 485206125
PubChem CID 163224105
Search Google for chemical match using the InChIKey UMSJPISUMQOUKS-LMZGTLAXSA-N
Search Google for chemicals with the same backbone UMSJPISUMQOUKS
UniChem Compound Search for chemical match using the InChIKey UMSJPISUMQOUKS-LMZGTLAXSA-N
UniChem Connectivity Search for chemical match using the InChIKey UMSJPISUMQOUKS-LMZGTLAXSA-N