MZ-101   Click here for help

GtoPdb Ligand ID: 13115

Synonyms: MZ101
Compound class: Synthetic organic
Comment: MZ-101 is a preclinical, small molecule, selective inhibitor of glycogen synthase 1 (GYS1; P13807) [1]. It was designed as a strategy for the treatment of glycogen storage disorders such as Pompe disease, via a mechanism that reduces glycogen synthesis and storage in muscle. Inhibition of GYS1 is proposed as an alternative/or adjunct to alpha glucosidase (GAA) enzyme replacement therapy for Pompe disease.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 86.16
Molecular weight 449.52
XLogP 2.91
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(C)C1=CC=C(C=C1)[C@H](C2=CC=CC=C2)NC(=O)[C@@H]3C[C@H](CN3C(=O)CC4=CN=NN4)F
Isomeric SMILES CC(C)C1=CC=C(C=C1)[C@@H](NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)CC3=CN=NN3)C4=CC=CC=C4
InChI InChI=1S/C25H28FN5O2/c1-16(2)17-8-10-19(11-9-17)24(18-6-4-3-5-7-18)28-25(33)22-12-20(26)15-31(22)23(32)13-21-14-27-30-29-21/h3-11,14,16,20,22,24H,12-13,15H2,1-2H3,(H,28,33)(H,27,29,30)/t20-,22+,24+/m1/s1
InChI Key VIXMWFGMNPKXHI-SFLYRZDNSA-N
References
1. Ullman JC, Mellem KT, Xi Y, Ramanan V, Merritt H, Choy R, Gujral T, Young LEA, Blake K, Tep S et al.. (2024)
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders.
Sci Transl Med, 16 (730): eadf1691. [PMID:38232139]