SPR741   Click here for help

GtoPdb Ligand ID: 13250

Synonyms: NAB741
Compound class: Peptide or derivative
Comment: SPR741 is a cationic peptide derived from polymyxin B. It is a potentiator molecule that acts by increasing the permeability of the outer membrane of Gram-negative bacteria [3]. It was designed to extend the spectrum and enhance the potency of existing antibacterial compounds and for use in combination therapies to treat severe infections caused by Gram-negative bacteria.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(C)C[C@H]1C(=O)N[C@@H](CCN)C(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC[C@@H](C(=O)N[C@@H](CCN)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N1)NC(=O)[C@@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)C
Isomeric SMILES C[C@H]([C@H]1C(=O)NCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCN)CCN)CC(C)C)CC2=CC=CC=C2)CCN)NC(=O)[C@@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)C)O
InChI InChI=1S/C44H73N13O13/c1-22(2)19-31-40(66)52-27(11-15-45)36(62)51-29(13-17-47)39(65)57-34(23(3)59)43(69)48-18-14-30(53-42(68)33(21-58)56-44(70)35(24(4)60)49-25(5)61)38(64)50-28(12-16-46)37(63)55-32(41(67)54-31)20-26-9-7-6-8-10-26/h6-10,22-24,27-35,58-60H,11-21,45-47H2,1-5H3,(H,48,69)(H,49,61)(H,50,64)(H,51,62)(H,52,66)(H,53,68)(H,54,67)(H,55,63)(H,56,70)(H,57,65)/t23-,24-,27+,28+,29+,30+,31+,32-,33-,34+,35+/m1/s1
InChI Key JBFNEVNUGGFPBQ-DDMCRLCFSA-N
Classification Click here for help
Compound class Peptide or derivative
IUPAC Name Click here for help
(2S,3R)-2-acetamido-3-hydroxy-N-[(2R)-3-hydroxy-1-oxo-1-[[(3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]propan-2-yl]butanamide
Synonyms Click here for help
NAB741
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo SPR741, NAB741
Other databases
CAS Registry No. 1179330-52-9 (source: Scifinder)
ChEMBL Ligand CHEMBL1631770
GtoPdb PubChem SID 491300032
PubChem CID 53323381
Search Google for chemical match using the InChIKey JBFNEVNUGGFPBQ-DDMCRLCFSA-N
Search Google for chemicals with the same backbone JBFNEVNUGGFPBQ
UniChem Compound Search for chemical match using the InChIKey JBFNEVNUGGFPBQ-DDMCRLCFSA-N
UniChem Connectivity Search for chemical match using the InChIKey JBFNEVNUGGFPBQ-DDMCRLCFSA-N