pravastatin

Ligand Id: 2953
Ligand name pravastatin

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 11
Topological polar surface area 124.29
Molecular weight 424.25
XLogP 2.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK


Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA (1991))
IUPAC Name
(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
International Nonproprietary Names
INN number INN
6070 pravastatin
Database Links
CAS Registry No. 81093-37-0 (source: Scifinder)
ChEMBL Ligand CHEMBL1144
DrugBank Ligand DB00175
PubChem CID 54687
Search Google for chemical match using the InChIKey TUZYXOIXSAXUGO-PZAWKZKUSA-N
Search Google for chemicals with the same backbone TUZYXOIXSAXUGO
Search PubMed clinical trials pravastatin
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Wikipedia Pravastatin
ZINC ZINC03798763
Comments
Pravastatin sodium is an odorless, white to off-white, fine or crystalline powder. It is a relatively polar hydrophilic compound with a partition coefficient (octanol/water) of 0.59 at a pH of 7.0. It is soluble in methanol and water (>300 mg/mL), soluble in isopropanol, and practically insoluble in acetone, acetonitrile, chloroform, and ether.