CXCL4

Ligand id: 3685

Name: CXCL4

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Synonyms
platelet factor 4 (PF4)
Comments
CXCL4 is a C-X-C motif chemokine first identified in megakaryocytes and platelets. It is a potent antiangiogenic chemokine and also promotes inflammatory fibrosis [3]. It can be used as a prognostic marker for the fibrosing autoimmune disease systemic sclerosis (scleroderma) [2]. A CXCR3 splice variant, CXCR3B, is a functional receptor for CXCL4 [1].
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
PF4 platelet factor 4 Human platelet factor 4 chemokine (C-X-C motif) ligand 4, CXCL4, platelet factor 4, SCYB4
Database Links
Ensembl Gene ENSG00000163737 (Hs)
Entrez Gene 5196 (Hs)
GtoPdb PubChem SID 178100574
Human Protein Atlas ENSG00000163737 (Hs)
OMIM 173460 (Hs)
RefSeq Nucleotide NM_002619 (Hs)
UniProtKB P02776 (Hs)
Wikipedia Platelet_factor_4