L701324

Ligand id: 4240

Name: L701324

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 58.56
Molecular weight 363.07
XLogP 5.8
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
7-chloro-2-hydroxy-3-(3-phenoxyphenyl)-1,4-dihydroquinolin-4-one
Synonyms
Names References
compund 13 [PMID: 8182696] 1
L-701,324
L-701324
Database Links
CAS Registry No. 142326-59-8 (source: Scifinder)
ChEMBL Ligand CHEMBL31741
PubChem CID 54682505
Search Google for chemical match using the InChIKey FLVRDMUHUXVRET-UHFFFAOYSA-N
Search Google for chemicals with the same backbone FLVRDMUHUXVRET
Comments
L701324 is an orally active, high affinity selective antagonist for the glycine site on the NMDA receptor [1]. The glycine binding site resides within the GluN1 subunit of the receptor.