amyloid β

Ligand id: 4865

Name: amyloid β

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
APP amyloid beta precursor protein Human prepro-amyloid beta A4 protein AD1, Alzheimer disease, amyloid beta (A4) precursor protein, peptidase nexin-II
Synonyms
amyloid β-peptide
beta-amyloid protein
Database Links
Ensembl Gene ENSG00000142192 (Hs)
UniProtKB P05067 (Hs)
Wikipedia Amyloid_beta
Comments
We give the sequence for the 42 amino acid peptide here, but note that use of the name β-amyloid generally refers to the ensemble of peptides of 40 to 43 residues excised from the precursor APP protein by the combined action of β- and γ-secretases. These peptides may be soluble monomers or oligomers and contribute to the formation of fibrils and plaques that are associated with Alzheimer's disease.

The amino acid sequences of alternative forms are;
1-40 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
1-42 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
1-43 DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIAT

So far we have annotated three types of target relationships for β-amyloid:
1) antibodies directed against the peptide forms for depletion
2) aggregation antagonists
3) imaging reagents for detection