IL-6

Ligand id: 4998

Name: IL-6

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
IL6 interleukin 6 Human prepro-interleukin 6 BSF2, HGF, HSF, IFNB2, IL-6, interleukin 6 (interferon, beta 2)
Synonyms
B-cell stimulatory factor 2 | CTL differentiation factor | hybridoma growth factor | interferon β2 | interleukin-6
Database Links
UniProtKB P05231 (Hs)
Wikipedia Interleukin_6
Comments
IL-6 is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. It is the originating member of a family of related cytokines that include IL-11, oncostatin M (OSM), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine factor 1/B-cell stimulating factor 3 (NNT-1), neuropoietin (NPN), IL-27, and IL-31 [5]. IL-6 is produced by T and B cells, macrophages, dendritic cells, and non-immune cells such as fibroblasts, endothelial cells, glial cells, keratinocytes, and placental syncytio- and extravillous trophoblasts.
The receptors for these cytokines (except IL-31) share a common signal transducing subunit gp130 (IL6ST).
IL-6 is involved in inflammation, infection responses and in the regulation of metabolic, regenerative, and neural processes.