TRAIL

Ligand id: 5065

Name: TRAIL

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF10 TNF superfamily member 10 Human prepro-tumor necrosis factor ligand superfamily member 10 Apo-2L, CD253, TL2, TRAIL, tumor necrosis factor (ligand) superfamily, member 10, tumor necrosis factor superfamily member 10
Synonyms
Apo-2 ligand (Apo-2L)
Database Links
Ensembl Gene ENSG00000121858 (Hs)
UniProtKB P50591 (Hs)
Wikipedia TRAIL
Comments
TRAIL is a cytokine of the tumor necrosis factor (TNF) ligand family. TRAIL binds to several TNF family receptors, activating MAPK8/JNK, caspase 8, and caspase 3. Its interaction with death receptors on tumor cells triggers apoptosis. Binding to decoy receptors may neutralise TRAIL activity. Because TRAIL exhibits much stronger apoptotic activity than other TNF family members, kills tumor cells more effectively than normal cells, and presents less risk of inducing an inflammatory repsonse following systemic administration, use of TRAIL as an anti-cancer therapeutic has been widely examined. Huang et al. (2017) [2] describe the development and potent anti-tumor activity of a TRAIL fusion protein nanoparticle formulation in a xenograft model [1]. To date, no pharmaceutical agents targeting TRAIL or its receptors in cancer have been approved.