tumour necrosis factor shed form

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Ligands
tumour necrosis factor shed form (Human)

Ligand id: 5074

Name: tumour necrosis factor shed form

Abbreviated name: TNF shed form

Species: Human

Summary
Biological activity
References
Structure
Similar ligands
Immunopharmacology

Classification
Compound class	Endogenous peptide in human, mouse or rat

Gene/Precursor

Gene symbol	Gene name	Species	Precursor protein name	Synonyms
TNF	tumor necrosis factor	Human	prepro-tumor necrosis factor	DIF, TNFA, TNF-alpha, TNFSF2, TNF superfamily, member 2, tumor necrosis factor (TNF superfamily, member 2)

Synonyms
cachectin
necrosin
TNF alpha soluble form
tumor necrosis factor soluble form

Synonyms

cachectin

necrosin

TNF alpha soluble form

tumor necrosis factor soluble form

Database Links
DrugBank Target	P01375 (Hs)
Ensembl Gene	ENSG00000204490 (Hs)
UniProtKB	P01375 (Hs)
Wikipedia	Tumor_necrosis_factor-alpha

Comments
TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation. The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand. Recombinant TNF is used as an immunostimulant under the INN tasonermin.

Comments

TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNFSF2 precursor is also cleaved into a membrane-bound form of the ligand. Recombinant TNF is used as an immunostimulant under the INN tasonermin.