tumour necrosis factor shed form

Ligand id: 5074

Name: tumour necrosis factor shed form

Abbreviated name: TNF shed form

Species: Human

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Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Tumor necrosis factor superfamily ligands
Synonyms
cachectin | necrosin | TNF alpha soluble form | tumor necrosis factor soluble form
Comments
TNFα is a pro-inflammatory, acute phase cytokine involved in systemic inflammation.
The TNF precursor is expressed as a membrane-bound ligand, which is cleaved by TACE/ADAM17 to form this shed (or 'soluble') bioactive cytokine containing just the extracellular domain, and that circulates predominantly as a homotrimer. Recombinant TNF is used as an immunostimulant under the INN tasonermin.
Circulating active TNF-α is the principal molecular target of the anti-TNF therapeutics infliximab and adalimumab. A smaller and longer acting anti-TNF biologic called V565 is in early stage clinical development [2]. V565 is a heavy chain only variable domain anti-TNF construct generated in Ilama and modified to further enhance resistance to protease-mediated degradation. It binds shed TNF-α with similar affinity to infliximab and adalimumab, and also inhibits biological responses mediated by membrane-bound TNF-α [2]. If this design strategy proves successful, V565 will be the first orally active anti-TNF therapy. V565 is being evaluated for potential to treat Crohn's disease (see Phase 2 study NCT02976129).
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
TNF tumor necrosis factor Human prepro-tumor necrosis factor DIF, TNFA, TNF-alpha, TNFSF2, TNF superfamily, member 2, tumor necrosis factor (TNF superfamily, member 2)
Database Links
CATH/Gene3D 2.60.120.40
DrugBank Target P01375 (Hs)
Ensembl Gene ENSG00000204490 (Hs)
GtoPdb PubChem SID 178101767
Human Protein Atlas ENSG00000204490 (Hs)
UniProtKB P01375 (Hs)
Wikipedia Tumor_necrosis_factor-alpha