OX-40 ligand

Ligand id: 5076

Name: OX-40 ligand

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands)Tumor necrosis factor superfamily ligands
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF4 TNF superfamily member 4 Human prepro-tumor necrosis factor ligand superfamily member 4 CD134L, CD252, gp34, OX40L, OX-40L, tax-transcriptionally activated glycoprotein 1, 34kD, tumor necrosis factor (ligand) superfamily, member 4, tumor necrosis factor superfamily member 4, TXGP1
Synonyms
glycoprotein Gp34 | TXGP-1
Database Links
Ensembl Gene ENSG00000117586 (Hs)
Human Protein Atlas ENSG00000117586 (Hs)
UniProtKB P23510 (Hs)
Wikipedia OX40L
Comments
OX40L (CD252) is the ligand for tumor necrosis factor receptor superfamily, member 4 (TNFRSF4, a.k.a. OX40 or CD134). OX40 is a secondary co-stimulatory immune checkpoint molecule expressed on activated T cells (requiring CD28 co-stimulatory signal), and OX40L is expressed on activated dendritic cells. The OX40/OX40L pair is involved in late T-cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models [4]. The OX40/OX40L pathway is being investigated for the development of novel anti-inflammatory therapeutics and anti-cancer drugs.
An antibody binding mouse OX40L