OX-40 ligand

Ligand id: 5076

Name: OX-40 ligand

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups CD molecules (ligands)Tumor necrosis factor superfamily ligands
Synonyms
glycoprotein Gp34 | TXGP-1
Comments
OX40L (CD252) is the ligand for tumor necrosis factor receptor superfamily, member 4 (TNFRSF4, a.k.a. OX40 or CD134). OX40 is a secondary co-stimulatory immune checkpoint molecule expressed on activated T cells (requiring CD28 co-stimulatory signal), and OX40L is expressed on activated dendritic cells. The OX40/OX40L pair is involved in late T-cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models [4]. The OX40/OX40L pathway is being investigated for the development of novel anti-inflammatory therapeutics and anti-cancer drugs.
An antibody binding mouse OX40L
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF4 TNF superfamily member 4 Human prepro-tumor necrosis factor ligand superfamily member 4 CD134L, CD252, gp34, OX40L, OX-40L, tax-transcriptionally activated glycoprotein 1, 34kD, tumor necrosis factor (ligand) superfamily, member 4, tumor necrosis factor superfamily member 4, TXGP1
Database Links
Ensembl Gene ENSG00000117586 (Hs)
GtoPdb PubChem SID 178101769
Human Protein Atlas ENSG00000117586 (Hs)
UniProtKB P23510 (Hs)
Wikipedia OX40L