SB203580

Ligand id: 5269

Name: SB203580

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 77.85
Molecular weight 377.1
XLogP 3.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine
Synonyms
PB 203580 | RWJ 64809 | SB-203580
Database Links
CAS Registry No. 152121-47-6
ChEMBL Ligand CHEMBL10
PubChem CID 176155
Search Google for chemical match using the InChIKey CDMGBJANTYXAIV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone CDMGBJANTYXAIV
Search UniChem for chemical match using the InChIKey CDMGBJANTYXAIV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone CDMGBJANTYXAIV
SynPHARM 78583 (in complex with mitogen-activated protein kinase 14)
Wikipedia SB_203580
Comments
SB203580 inhibits p38 MAPK enzymes, with some selectivity for p38α. The compound has been used to dissect the p38 signalling pathway and to determine the binding mode and differentiate functions between the four p38 MAP kinase homologues [4,6]. The hydrochloride salt is water-soluble.