linifanib

Ligand id: 5657

Name: linifanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 95.83
Molecular weight 375.15
XLogP 5.39
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea
International Nonproprietary Names
INN number INN
9195 linifanib
Synonyms
ABT 869 | ABT-869
Database Links
CAS Registry No. 796967-16-3
ChEMBL Ligand CHEMBL223360
PubChem CID 11485656
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Wikipedia Linifanib
Comments
Linifanib is a potent, orally active inhibitor of several receptor tyrosine kinases (RTKs), with principal targets being FLT3, CSF1R and VEGFR2.