pictilisib

Ligand id: 5682

Name: pictilisib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 144.17
Molecular weight 513.16
XLogP 1.31
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine
International Nonproprietary Names
INN number INN
9417 pictilisib
Synonyms
GDC-0941 | GDC0941 | GNE 0941 | pictrelisib
Database Links
CAS Registry No. 957054-30-7
ChEBI CHEBI:65326
ChEMBL Ligand CHEMBL521851
PubChem CID 17755052
RCSB PDB Ligand GD9
Search Google for chemical match using the InChIKey LHNIIDJUOCFXAP-UHFFFAOYSA-N
Search Google for chemicals with the same backbone LHNIIDJUOCFXAP
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Search UniChem for chemical match using the InChIKey LHNIIDJUOCFXAP-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone LHNIIDJUOCFXAP
SynPHARM 81100 (in complex with phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
84482 (in complex with phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)
Comments
Pictilisib is a potent and orally bioavailable inhibitor of Class I phosphatidylinositol-3 kinase family proteins [3-4].