IL-36α

Ligand id: 5881

Name: IL-36α

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
IL36A interleukin 36, alpha Human interleukin-36 alpha FIL1, FIL1E, IL1(EPSILON), IL1F6, IL-1F6, interleukin 1 family, member 6 (epsilon), MGC129552, MGC129553
Synonyms
FIL1 epsilon | interleukin-1 epsilon (IL-1 epsilon)
Database Links
Ensembl Gene ENSG00000136694 (Hs)
Human Protein Atlas ENSG00000136694 (Hs)
UniProtKB Q9UHA7 (Hs)
Wikipedia IL36A
Comments
IL-36α, IL-36β, IL-36γ, and IL-36 receptor antagonist form the IL-36 group of cytokines and are a subset of the IL-1 cytokine family. IL-36α, IL-36β, IL-36γ are agonists of the IL-36 receptor complex (IL1RL2/IL1R-rp2/IL-36 receptor) and activate NF-κB and MAP kinase pathways inducing a pro-inflammatory response. The IL-36 receptor antagonist as its name suggests antagonises signalling by the IL-36 receptor agonists to reduce their pro-inflammatory function.