Akt inhibitor VIII

Ligand id: 5921

Name: Akt inhibitor VIII

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 90.04
Molecular weight 551.24
XLogP 7.27
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-{1-[(4-{6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl}phenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
Synonyms
isozyme-selective, Akti-1/2
Database Links
CAS Registry No. 612847-09-3
ChEMBL Ligand CHEMBL258844
PubChem CID 10196499
Search Google for chemical match using the InChIKey BIWGYFZAEWGBAL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BIWGYFZAEWGBAL
Comments
Akt Inhibitor VIII (compound 16h [3]) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt (protein kinase B), with selectivity for Akt1/2 over Akt3 [3].