VEGF receptor 2 kinase inhibitor II

Ligand id: 6054

Name: VEGF receptor 2 kinase inhibitor II

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 44.89
Molecular weight 342.04
XLogP 4.3
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(3Z)-5-bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Synonyms
indolin-2-one deriv. 4b
Database Links
CAS Registry No. 288144-20-7
ChEMBL Ligand CHEMBL88606
PubChem CID 5329155
Search Google for chemical match using the InChIKey RFHPWPWVGFSLOP-ZROIWOOFSA-N
Search Google for chemicals with the same backbone RFHPWPWVGFSLOP
Search UniChem for chemical match using the InChIKey RFHPWPWVGFSLOP-ZROIWOOFSA-N
Search UniChem for chemicals with the same backbone RFHPWPWVGFSLOP
Comments
This is compound 4b in [3]. This paper refers to [4] for the method used for the kinase assay. However, this referenced article does not make clear which species isozymes were used in the experiments. We have mapped the associated data with the human VEGFR2.