Ligand id: 6469

Name: lepirudin

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Compound class Peptide or derivative
Approved drug? Yes (FDA (1998))
International Nonproprietary Names
INN number INN
7355 lepirudin
1-L-leucine-2-L-threonine-63-desulfohirudin | Refludan®
Discontinued (not withdrawn). The drug is a recombinant form of hirudin, the salivary anticoagulant found in leeches (see UniProt P01050), but has two amino acid modifications; substitution of Leu1 for Ile and no sulfate group on Tyr63. The PubChem entry linked to above represents the chemical structure of Lepirudin.
Database Links
CAS Registry No. 138068-37-8 (source: PubChem)
ChEMBL Ligand CHEMBL1201666
DrugBank Ligand DB00001
GtoPdb PubChem SID 178103083
PubChem CID 16132441
Search PubMed clinical trials lepirudin
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Wikipedia Lepirudin