eltrombopag

Ligand id: 6961

Name: eltrombopag

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 114.59
Molecular weight 442.16
XLogP 7.39
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2008))
IUPAC Name
3-(3-{2-[(4Z)-1-(3,4-dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazin-1-yl}-2-hydroxyphenyl)benzoic acid
International Nonproprietary Names
INN number INN
8655 eltrombopag
Synonyms
AMG531 | Promacta® | Revolade® | SB-497115-GR
Database Links
CAS Registry No. 496775-61-2 (source: Scifinder)
ChEMBL Ligand CHEMBL461101
DrugBank Ligand DB06210
GtoPdb PubChem SID 178103542
PubChem CID 66583167
Search Google for chemical match using the InChIKey XDXWLKQMMKQXPV-QYQHSDTDSA-N
Search Google for chemicals with the same backbone XDXWLKQMMKQXPV
Search PubMed clinical trials eltrombopag
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Search UniChem for chemical match using the InChIKey XDXWLKQMMKQXPV-QYQHSDTDSA-N
Search UniChem for chemicals with the same backbone XDXWLKQMMKQXPV
Wikipedia Eltrombopag
Comments
Eltrombopag is a thrombopoietin receptor agonist that increases production of platelets. The structure shown here represents the compound with double bond stereochemistry as stipulated in the INN record for this drug. Representations on other chemistry databases may show alternative tautomers. The marketed drug contains eltrombopag olamine (PubChem CID 71719015, again note tautomer difference).