pinometostat

Ligand id: 7019

Name: pinometostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 151.23
Molecular weight 562.34
XLogP 4.3
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
International Nonproprietary Names
INN number INN
9964 pinometostat
Synonyms
EPZ 5676 | EPZ-5676 | EPZ5676
Database Links
CAS Registry No. 1380288-87-8
ChEMBL Ligand CHEMBL3087499
PubChem CID 57345410
RCSB PDB Ligand EP6
Search Google for chemical match using the InChIKey LXFOLMYKSYSZQS-LURJZOHASA-N
Search Google for chemicals with the same backbone LXFOLMYKSYSZQS
Search PubMed clinical trials pinometostat
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Search PubMed titles/abstracts pinometostat
Search UniChem for chemical match using the InChIKey LXFOLMYKSYSZQS-LURJZOHASA-N
Search UniChem for chemicals with the same backbone LXFOLMYKSYSZQS
SynPHARM 79340 (in complex with DOT1 like histone lysine methyltransferase)
Comments
Pinometostat acts as a DOT1-like histone H3K79 methyltransferase (DOT1L) inhibitor, and is being investigated for its antineoplastic action.