Ligand id: 7035

Name: H3-CoA-20

Compound class Peptide or derivative
This compound is a member of a new class of histone acetyltransferase inhibitors known as bisubstrate inhibitors. It is formed from coenzyme A modified with peptide side chains of histone H3 sequence. See Lau et al (2000) for structural details [2]. The 3 dimensional structure of this compound in complex with GCN5 histone acetyltransferase (KAT2A) has been published [3]. For a review of compounds being investigated as modulators of histone-modifying enzyme activity see [1].
Database Links
ChEMBL Ligand CHEMBL1221562
GtoPdb PubChem SID 178103614