azathioprine   Click here for help

GtoPdb Ligand ID: 7120

Synonyms: Azasan® | BW-57-322 | Imuran® | Jayempi®
Approved drug Immunopharmacology Ligand
azathioprine is an approved drug (FDA (1968), EMA (2021))
Compound class: Synthetic organic
Comment: Azathioprine is an immunosuppressive antimetabolite. The active drug is believed to be mercaptopurine.
Marketed formulations may contain azathioprine sodium (PubChem CID 23678403).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: azathioprine

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 143.4
Molecular weight 277.04
XLogP 0.67
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Cn1cnc(c1Sc1ncnc2c1nc[nH]2)N(=O)=O
Isomeric SMILES Cn1cnc(c1Sc1ncnc2c1nc[nH]2)N(=O)=O
InChI InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)
InChI Key LMEKQMALGUDUQG-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1968), EMA (2021))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
Is prodrug? Yes
Active form mercaptopurine
IUPAC Name Click here for help
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-9H-purine
International Nonproprietary Names Click here for help
INN number INN
1291 azathioprine
Synonyms Click here for help
Azasan® | BW-57-322 | Imuran® | Jayempi®
Database Links Click here for help
BitterDB Ligand 56
CAS Registry No. 446-86-6
ChEMBL Ligand CHEMBL1542
DrugBank Ligand DB00993
DrugCentral Ligand 269
GtoPdb PubChem SID 178103697
Immunopaedia Search azathioprine
PubChem CID 2265
Search Google for chemical match using the InChIKey LMEKQMALGUDUQG-UHFFFAOYSA-N
Search Google for chemicals with the same backbone LMEKQMALGUDUQG
Search PubMed clinical trials azathioprine
Search PubMed titles azathioprine
Search PubMed titles/abstracts azathioprine
UniChem Compound Search for chemical match using the InChIKey LMEKQMALGUDUQG-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey LMEKQMALGUDUQG-UHFFFAOYSA-N
Wikipedia Azathioprine

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Tocris
Azathioprine (links to external site)
Cat. No. 4099