(R)-flurbiprofen

Ligand id: 7340

Name: (R)-flurbiprofen

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 37.3
Molecular weight 244.09
XLogP 5.51
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid
International Nonproprietary Names
INN number INN
3220 flurbiprofen
8417 tarenflurbil
Synonyms
MPC-7869
Database Links
CAS Registry No. 51543-40-9 (source: Scifinder)
ChEBI CHEBI:38666
ChEMBL Ligand CHEMBL190083
DrugBank Ligand DB05289
PubChem CID 92337
RCSB PDB Ligand FLR
Search Google for chemical match using the InChIKey SYTBZMRGLBWNTM-SNVBAGLBSA-N
Search Google for chemicals with the same backbone SYTBZMRGLBWNTM
Search PubMed clinical trials tarenflurbil
Search PubMed titles tarenflurbil
Search PubMed titles/abstracts tarenflurbil
Search UniChem for chemical match using the InChIKey SYTBZMRGLBWNTM-SNVBAGLBSA-N
Search UniChem for chemicals with the same backbone SYTBZMRGLBWNTM
Wikipedia Tarenflurbil
Comments
Tarenflurbil or R-flurbiprofen, is the single enantiomer of the racemate NSAID flurbiprofen. Research and trials for Alzheimer's disease were conducted by Myriad Genetics but the company discontinued development in 2008. This compound is the archetypal γ-secretase modulator (GSM) that blocks γ-secretase cleavage of amyloid-β protein precursor (AβPP) to generate the longer, 42-residue amyloid-β (Aβ42) without changing the production of total Aβ (e.g. CHF5074) [2].