RGFP966

Ligand id: 7500

Name: RGFP966

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 72.94
Molecular weight 362.15
XLogP 5.4
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2E)-N-(2-amino-4-fluorophenyl)-3-{1-[(2E)-3-phenylprop-2-en-1-yl]-1H-pyrazol-4-yl}prop-2-enamide
Synonyms
RGFP-966
Database Links
PubChem CID 56650312
Search Google for chemical match using the InChIKey BLVQHYHDYFTPDV-VCABWLAWSA-N
Search Google for chemicals with the same backbone BLVQHYHDYFTPDV
Search UniChem for chemical match using the InChIKey BLVQHYHDYFTPDV-VCABWLAWSA-N
Search UniChem for chemicals with the same backbone BLVQHYHDYFTPDV
Comments
RGFP966 is a selective inhibitor of histone deacetylase 3 (HDAC3) [1]. In rodent studies, RGFP966-induced inhibition of HDAC3 appears to enhance memory processes involved in extinction of drug-seeking behaviour [1].