varlitinib

Ligand id: 7645

Name: varlitinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 121.79
Molecular weight 466.1
XLogP 4.52
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
International Nonproprietary Names
INN number INN
9187 varlitinib
Synonyms
ARRY-334543 | ARRY334543
Database Links
CAS Registry No. 845272-21-1 (source: Scifinder)
ChEMBL Ligand CHEMBL2103842
PubChem CID 42642648
Search Google for chemical match using the InChIKey UWXSAYUXVSFDBQ-CYBMUJFWSA-N
Search Google for chemicals with the same backbone UWXSAYUXVSFDBQ
Search PubMed clinical trials varlitinib
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Search PubMed titles/abstracts varlitinib
Search UniChem for chemical match using the InChIKey UWXSAYUXVSFDBQ-CYBMUJFWSA-N
Search UniChem for chemicals with the same backbone UWXSAYUXVSFDBQ
Comments
Varlitinib selectively and reversibly binds to both EGFR and HER2 and prevents their phosphorylation and activation, and is being investigated for the treatment of some types of cancer. Some bioactivity data may be linked to the tosylate salt (PubChem CID 56842258).
This clinical candidate has completed Phase II clinical trials. Click here to view varlitinib trials registered with ClinicalTrials.gov.