SRT1720

Ligand id: 7703

Name: SRT1720

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 115.69
Molecular weight 469.17
XLogP 3.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide
Database Links
CAS Registry No. 925434-55-5
ChEMBL Ligand CHEMBL257991
PubChem CID 24180125
RCSB PDB Ligand SR7
Search Google for chemical match using the InChIKey IASPBORHOMBZMY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IASPBORHOMBZMY
Search UniChem for chemical match using the InChIKey IASPBORHOMBZMY-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone IASPBORHOMBZMY
Wikipedia SRT1720
Comments
SRT1720 is a selective SIRT1 activator. SRT1720 binds to the SIRT1 enzyme–peptide substrate complex at an allosteric site amino-terminal to the catalytic domain [2]. In vivo studies show that SIRT1 activation has the potential to improve insulin sensitivity in animal models of obesity, and improve glucose homeostasis [2]. This indicates the potential of such compounds as treatment for type II diabetes.