RGB-286638

Ligand id: 7744

Name: RGB-286638

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 115.06
Molecular weight 545.28
XLogP 1.4
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[2,1-d]pyrazol-5-yl]-3-morpholin-4-ylurea
Synonyms
RGB 286638 | RGB286638
Database Links
CAS Registry No. 784210-88-4
PubChem CID 11285002
Search Google for chemical match using the InChIKey XLSYZSRXVVCHLS-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XLSYZSRXVVCHLS
Search UniChem for chemical match using the InChIKey XLSYZSRXVVCHLS-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone XLSYZSRXVVCHLS
Comments
RGB-286638 is a multi-targeted kinase inhibitor. It inhibits transcriptional-type CDKs (cyclin dependent kinases) such as CDK9, to achieve an anti-multiple myeloma effect which is independent of p53 status [1], providing a proof of concept which could lead to the development of compounds with activity in p53 deleted multiple myeloma.
A Phase I safety and tolerability study, NCT01168882, was withdrawn from ClinicalTrials.gov (2012), although results of this study have been published.[2].