poziotinib

Ligand id: 7903

Name: poziotinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 76.58
Molecular weight 490.1
XLogP 3.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one
International Nonproprietary Names
INN number INN
9736 poziotinib
Synonyms
HM781-36B | NOV120101
Database Links
CAS Registry No. 1092364-38-9
PubChem CID 25127713
Search Google for chemical match using the InChIKey LPFWVDIFUFFKJU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone LPFWVDIFUFFKJU
Search PubMed clinical trials poziotinib
Search PubMed titles poziotinib
Search PubMed titles/abstracts poziotinib
Search UniChem for chemical match using the InChIKey LPFWVDIFUFFKJU-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone LPFWVDIFUFFKJU
Comments
Poziotinib is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with antineoplastic activity [1-2].