golvatinib

Ligand id: 7956

Name: golvatinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 12
Topological polar surface area 119.14
Molecular weight 633.29
XLogP 4.78
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N'-[2-fluoro-4-[2-[[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]amino]pyridin-4-yl]oxyphenyl]-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
International Nonproprietary Names
INN number INN
9565 golvatinib
Synonyms
E-7050 | E7050
Database Links
CAS Registry No. 928037-13-2
ChEMBL Ligand CHEMBL3039525
PubChem CID 16118392
RCSB PDB Ligand GV0
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Comments
Golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity [1]. It is the first kinase inhibitor with this dual action.