MK-2461

Ligand id: 7962

Name: MK-2461

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 124.03
Molecular weight 495.16
XLogP 0.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
Synonyms
MK 2461
Database Links
CAS Registry No. 917879-39-1
ChEMBL Ligand CHEMBL1822792
PubChem CID 44137946
Search Google for chemical match using the InChIKey JGEBLDKNWBUGRZ-HXUWFJFHSA-N
Search Google for chemicals with the same backbone JGEBLDKNWBUGRZ
Search UniChem for chemical match using the InChIKey JGEBLDKNWBUGRZ-HXUWFJFHSA-N
Search UniChem for chemicals with the same backbone JGEBLDKNWBUGRZ
Comments
MK-2461 is a novel ATP-competitive inhibitor of mutant activated c-Met and also exhibits significant inhibitory activities against fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor, and other receptor tyrosine kinases [1].