SB 216763

Ligand id: 8015

Name: SB 216763

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 51.1
Molecular weight 370.03
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
Synonyms
SB-216763 | SB216763
Database Links
CAS Registry No. 280744-09-4
ChEMBL Ligand CHEMBL102714
PubChem CID 176158
Search Google for chemical match using the InChIKey JCSGFHVFHSKIJH-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JCSGFHVFHSKIJH
Search UniChem for chemical match using the InChIKey JCSGFHVFHSKIJH-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone JCSGFHVFHSKIJH
Comments
SB 216763 is a potent and selective inhibitor of glycogen synthase kinase 3 (GSK-3), equipotent at GSK-3α and GSK-3β isozymes [2]. The compound is an investigational tool which may be used to help clarify the role played by GSK-3 in cellular signalling.