PD166285

Ligand id: 8183

Name: PD166285

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 9
Topological polar surface area 70.59
Molecular weight 511.15
XLogP 5.2
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-(2,6-dichlorophenyl)-2-[[4-(2-diethylaminoethoxy)phenyl]amino]-8-methylpyrido[6,5-d]pyrimidin-7-one
Synonyms
PD-166285 | PD0166285 [5]
Database Links
BindingDB Ligand 3096
CAS Registry No. 185039-89-8
ChEMBL Ligand CHEMBL49120
PubChem CID 5311382
Search Google for chemical match using the InChIKey IFPPYSWJNWHOLQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IFPPYSWJNWHOLQ
Search UniChem for chemical match using the InChIKey IFPPYSWJNWHOLQ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone IFPPYSWJNWHOLQ
Comments
PD166285 was originally reported as a tyrosine kinase inhibitor [1-2,4], and has subsequently been identified as an inhibitor of Wee1 [5] and Myt1 (PKMYT1) [3], two cyclin-dependent kinase (CDK) inhibitory kinases involved in regulating the cell cycle.