UNC1215

Ligand id: 8232

Name: UNC1215

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 59.13
Molecular weight 529.34
XLogP 5.27
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-phenyl-2,5-bis[4-(pyrrolidin-1-yl)piperidine-1-carbonyl]aniline
Database Links
CAS Registry No. 1415800-43-9
ChEMBL Ligand CHEMBL2426364
PubChem CID 57339144
RCSB PDB Ligand UWN
Search Google for chemical match using the InChIKey PQOOIERVZAXHBP-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PQOOIERVZAXHBP
Search UniChem for chemical match using the InChIKey PQOOIERVZAXHBP-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone PQOOIERVZAXHBP
Comments
UNC1215 was delevoped in a collaboration between the SGC (Structural Genomics Consortium) and the Center for Integrative Chemical Biology and Drug Discovery (CICBDD) at The University of North Carolina. It is the first chemical probe for a Kme (methyl-lysine recognition domain)-binding protein. UNC1215 is reported to be a potent and selective modulator of the Kme reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors [1]. Click here to link to the SGC's full list of epigenetics probes.