palovarotene

Ligand id: 8276

Name: palovarotene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 55.12
Molecular weight 414.23
XLogP 9.97
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid
International Nonproprietary Names
INN number INN
9025 palovarotene
Synonyms
Clementia® (proposed trade name) | R-667 | Ro-3300074
Database Links
PubChem CID 10295295
Search Google for chemical match using the InChIKey YTFHCXIPDIHOIA-DHZHZOJOSA-N
Search Google for chemicals with the same backbone YTFHCXIPDIHOIA
Search PubMed clinical trials palovarotene
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Search UniChem for chemical match using the InChIKey YTFHCXIPDIHOIA-DHZHZOJOSA-N
Search UniChem for chemicals with the same backbone YTFHCXIPDIHOIA
Comments
Palovarotene is a retinoic acid receptor gamma (RAR-γ) agonist. This compound was originally investegated for its ability to repair alveolar damage in emphysema [1,3], but has subsequently been repurposed as a potential treatment for fibrodysplasia ossificans progressiva (FOP).