mongersen

Ligand id: 8277

Name: mongersen

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Synthetic organic
International Nonproprietary Names
INN number INN
9926 mongersen
Synonyms
GED-0301
Database Links
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Comments
Mongersen is a phosphorothioate single-stranded oligonucleotide matching the region 107–128 (5′-GCTGCGGGGAGAAGGGGCGAC-3′) of the human Smad7 complementary DNA sequence. The antisense oligonucleotide sequence is (3'-5')d(P-thio)(G-T-m5C-G-C-C-C-C-T-T-C-T-C-C-C-m5C-G-C-A-G-C), where m5C represents 2’-deoxy-5-methyl-P-thiocytidylyl bases.
Mongersen is being investigated as a treatment for the Smad7-induced colitis associated with Crohn's disease and irritable bowel disease (IBD).