talampanel

Ligand id: 8279

Name: talampanel

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 77.15
Molecular weight 337.14
XLogP 3.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[(8R)-5-(4-aminophenyl)-8-methyl-8,9-dihydro-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-7-yl]ethanone
International Nonproprietary Names
INN number INN
7820 talampanel
Synonyms
GYKI 537773 | LY-300164 | LY300164
Database Links
CAS Registry No. 161832-65-1
ChEMBL Ligand CHEMBL61872
DrugBank Ligand DB04982
PubChem CID 164509
Search Google for chemical match using the InChIKey JACAAXNEHGBPOQ-LLVKDONJSA-N
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Search UniChem for chemical match using the InChIKey JACAAXNEHGBPOQ-LLVKDONJSA-N
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Wikipedia Talampanel
Comments
Talampanel is a non-competitive antagonist of the AMPA receptors, a family of ionotropic glutamate receptors of the central nervous system. The compound shows some selectivity for GluA1 and GluA2 over GluA3 and GluA4 [2].