Synonyms: CK-2017357
Compound class:
Synthetic organic
Comment: Tirasemtiv acts as an activator of the fast skeletal muscle (type II) troponin complex [4]. The compound is being investigated as a potential treatment for diseases and conditions associated with aging, muscle weakness and wasting or neuromuscular dysfunction [4] (e.g. amyotrophic lateral sclerosis [5], myasthenia gravis and claudication [2]). In clinical trial tirasemtiv was not well tolerated, and this was likely a contributory factor to its lack of significant efficacy.
|
|
Classification | |
Compound class | Synthetic organic |
IUPAC Name |
5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one |
International Nonproprietary Names | |
INN number | INN |
9555 | tirasemtiv |
Synonyms |
CK-2017357 |
Database Links | |
CAS Registry No. | 1005491-15-3 |
ChEMBL Ligand | CHEMBL3039529 |
GtoPdb PubChem SID | 252166492 |
PubChem CID | 23729157 |
RCSB PDB Ligand | W97 |
Search Google for chemical match using the InChIKey | RSQGZEAXODVTOL-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | RSQGZEAXODVTOL |
Search PubMed clinical trials | tirasemtiv |
Search PubMed titles | tirasemtiv |
Search PubMed titles/abstracts | tirasemtiv |
UniChem Compound Search for chemical match using the InChIKey | RSQGZEAXODVTOL-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RSQGZEAXODVTOL-UHFFFAOYSA-N |