GLPG0974

Ligand id: 8417

Name: GLPG0974

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 106.16
Molecular weight 484.12
XLogP 4.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-[[(2R)-1-(1-benzothiophene-3-carbonyl)-2-methylazetidine-2-carbonyl]-[(3-chlorophenyl)methyl]amino]butanoic acid
Synonyms
compound 99 [PMID 25380412]
Database Links
PubChem CID 57520598
Search Google for chemical match using the InChIKey MPMKMQHJHDHPBE-RUZDIDTESA-N
Search Google for chemicals with the same backbone MPMKMQHJHDHPBE
Search UniChem for chemical match using the InChIKey MPMKMQHJHDHPBE-RUZDIDTESA-N
Search UniChem for chemicals with the same backbone MPMKMQHJHDHPBE
Comments
GLPG0974 is a lead clinical development candidate compound which acts as an antagonist of the free fatty acid receptor 2 (FFA2) [3]. FFA2 is a GPCR involved in the mediation of inflammatory responses.