roxadustat

Ligand id: 8454

Name: roxadustat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 108.75
Molecular weight 352.11
XLogP 3.72
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-[[4-hydroxy-1-methyl-7-(phenoxy)isoquinoline-3-carbonyl]amino]acetic acid
International Nonproprietary Names
INN number INN
9717 roxadustat
Synonyms
ASP-1517 | ASP1517 | FG-4592 | FG4592
Database Links
CAS Registry No. 808118-40-3
ChEMBL Ligand CHEMBL2338329
PubChem CID 11256664
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Search UniChem for chemical match using the InChIKey YOZBGTLTNGAVFU-UHFFFAOYSA-N
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Comments
Roxadustat is a compound which inhibits hypoxia inducible factor prolyl hydroxylase (HIF-PH) activity. HIF-PH inhibitors are being investigated as novel therapies for anemia, especially anemia caused by chronic kindney disease (CKD) [2]. It is hoped that HIF-PH inhibitors will provide a more effective alternative to the use of erythropoetin replacement therapy plus iron supplementation in CKD patients.