MQ1

Ligand id: 8587

Name: MQ1

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 54.46
Molecular weight 429.24
XLogP 5.09
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
4-(cyclopropylmethoxy)-N-[8-methyl-3-[(1R)-1-pyrrolidin-1-ylethyl]quinolin-7-yl]benzamide
Synonyms
compound (R)-10a [1] | MQ-1
Database Links
ChEMBL Ligand CHEMBL2059420
PubChem CID 57521365
Search Google for chemical match using the InChIKey DFWKNBVJNXPUBW-LJQANCHMSA-N
Search Google for chemicals with the same backbone DFWKNBVJNXPUBW
Search UniChem for chemical match using the InChIKey DFWKNBVJNXPUBW-LJQANCHMSA-N
Search UniChem for chemicals with the same backbone DFWKNBVJNXPUBW
Comments
MQ1 is reported as a negative allosteric modulator (NAM) of the melanin-concentrating hormone receptor 1 (MCHR1) [1-2]. Antagonists and NAMs of MCHR1 are being investigated for their potential to provide anti-obesity therapies.