JZL195

Ligand id: 8606

Name: JZL195

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 85.15
Molecular weight 433.16
XLogP 6.26
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(4-nitrophenyl) 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
Synonyms
JZL 195 | JZL-195
Database Links
CAS Registry No. 1210004-12-8 (source: PubChem)
ChEMBL Ligand CHEMBL606201
PubChem CID 46232606
Search Google for chemical match using the InChIKey QNYRAEKLMNDRFY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QNYRAEKLMNDRFY
Search UniChem for chemical match using the InChIKey QNYRAEKLMNDRFY-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone QNYRAEKLMNDRFY
Comments
JZL195 was first reported as a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL, a.k.a. MAGL) in 2009 [5]. Animal experiments suggest that dual FAAH/MAGL inhibitiors may have improved analgesic effects against neuropathic pain, in comparison to selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists [1-2,4,6].
JZL195 has since been reported to also inhibit acyloxyacyl hydrolase (AOAH) [3]