CCK-8   Click here for help

GtoPdb Ligand ID: 864

Synonyms: CCK-8 (sulphated) | cholecystokinin 8 | cholecystokinin fragment 26-33 amide (sulphated)
Compound class: Endogenous peptide in human, mouse or rat
Comment: The sulphated form of CCK-8. A synthetic variant, desulphated CCK-8 also exists.
Species: Human, Mouse, Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: cck-8, cholecystokinin

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CSCCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N)Cc1ccccc1)CC(=O)O)CCSC)Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C(CC(=O)O)N)Cc1ccc(cc1)OS(=O)(=O)O
Isomeric SMILES CSCC[C@@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)CC(=O)O)CCSC)Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)Cc1ccc(cc1)OS(=O)(=O)O
InChI InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
InChI Key IZTQOLKUZKXIRV-YRVFCXMDSA-N
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
IUPAC Name Click here for help
(3S)-3-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-hydroxy-4-oxobutanoyl]amino]-3-(4-sulfooxyphenyl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]acetyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
International Nonproprietary Names Click here for help
INN number INN
3617 sincalide
Synonyms Click here for help
CCK-8 (sulphated) | cholecystokinin 8 | cholecystokinin fragment 26-33 amide (sulphated)
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CCK cholecystokinin Human prepro-cholecystokinin -
Cck cholecystokinin Mouse prepro-cholecystokinin -
Cck cholecystokinin Rat prepro-cholecystokinin cholecystokinin
Database Links Click here for help
Specialist databases
GPCRdb Ligand CCK-8
Other databases
CAS Registry No. 25126-32-3 (source: Scifinder)
ChEMBL Ligand CHEMBL1121
DrugCentral Ligand 4627
Ensembl Gene ENSRNOG00000019321 (Rn), ENSMUSG00000032532 (Mm), ENSG00000187094 (Hs)
GtoPdb PubChem SID 135651651
Human Protein Atlas ENSG00000187094 (Hs)
PubChem CID 9833444
Search Google for chemical match using the InChIKey IZTQOLKUZKXIRV-YRVFCXMDSA-N
Search Google for chemicals with the same backbone IZTQOLKUZKXIRV
Search PubMed clinical trials sincalide
Search PubMed titles sincalide
Search PubMed titles/abstracts sincalide
UniChem Compound Search for chemical match using the InChIKey IZTQOLKUZKXIRV-YRVFCXMDSA-N
UniChem Connectivity Search for chemical match using the InChIKey IZTQOLKUZKXIRV-YRVFCXMDSA-N
UniProtKB P01355 (Rn), P09240 (Mm), P06307 (Hs)
Wikipedia Sincalide

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Tocris
CCK Octapeptide, sulfated (links to external site)
Cat. No. 1166