finerenone

Home
Ligands
finerenone

Ligand id: 8678

Name: finerenone

Structure and Physico-chemical Properties

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	5
Hydrogen bond donors	2
Rotatable bonds	5
Topological polar surface area	110.26
Molecular weight	378.17
XLogP	1.93
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Classification
Compound class	Synthetic organic

IUPAC Name
(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

IUPAC Name

(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide

Synonyms
BAY 94-8862

Synonyms

BAY 94-8862

Database Links
GtoPdb PubChem SID	252166878
PubChem CID	60150535
Search Google for chemical match using the InChIKey	BTBHLEZXCOBLCY-QGZVFWFLSA-N
Search Google for chemicals with the same backbone	BTBHLEZXCOBLCY
Search UniChem for chemical match using the InChIKey	BTBHLEZXCOBLCY-QGZVFWFLSA-N
Search UniChem for chemicals with the same backbone	BTBHLEZXCOBLCY

Comments
Finerenone (BAY 94-8862) is a next generation oral, non-steroidal Mineralocorticoid Receptor antagonist which blocks the deleterious effects of aldosterone. Finerenone is currently in clinical Phase IIb development for the treatment of worsening chronic heart failure [2], as well as diabetic nephropathy.

Comments

Finerenone (BAY 94-8862) is a next generation oral, non-steroidal Mineralocorticoid Receptor antagonist which blocks the deleterious effects of aldosterone. Finerenone is currently in clinical Phase IIb development for the treatment of worsening chronic heart failure [2], as well as diabetic nephropathy.