gilteritinib

Ligand id: 8708

Name: gilteritinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 121.11
Molecular weight 552.35
XLogP 1.78
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
International Nonproprietary Names
INN number INN
10048 gilteritinib
Synonyms
ASP-2215 | ASP2215
Database Links
CAS Registry No. 1254053-43-4 (source: PubChem)
ChEMBL Ligand CHEMBL3301622
PubChem CID 49803313
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Comments
Gilteritinib is an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-related tyrosine kinase 3 (FLT3), AXL and anaplastic lymphoma kinase (ALK), with potential antineoplastic activity.