oprozomib

Ligand id: 8739

Name: oprozomib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 17
Topological polar surface area 176.49
Molecular weight 532.2
XLogP 1.34
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
International Nonproprietary Names
INN number INN
9597 oprozomib
Synonyms
ONX 0912 | ONX-0912 | PR-047
Database Links
CAS Registry No. 935888-69-0 (source: INN document)
PubChem CID 25067547
Search Google for chemical match using the InChIKey SWZXEVABPLUDIO-WSZYKNRRSA-N
Search Google for chemicals with the same backbone SWZXEVABPLUDIO
Search PubMed clinical trials oprozomib
Search PubMed titles oprozomib
Search PubMed titles/abstracts oprozomib
Search UniChem for chemical match using the InChIKey SWZXEVABPLUDIO-WSZYKNRRSA-N
Search UniChem for chemicals with the same backbone SWZXEVABPLUDIO
Comments
Oprozomib is an orally bioavailable derivative of carfilzomib, with similar biological action, i.e. inhibition of the chymotrypsin-like activity (a.k.a. β5 activity) of the proteasome [1-2]. This is compound 58 in [4].