fosbretabulin

Ligand id: 8857

Name: fosbretabulin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 113.49
Molecular weight 396.1
XLogP 2.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Is prodrug? Yes
Active form combretastatin A4
IUPAC Name
[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] dihydrogen phosphate
International Nonproprietary Names
INN number INN
8966 fosbretabulin
Synonyms
CA4DP | combretastatin A4 phosphate | fosbretabulin disodium | fosbretabulin tromethamine
Database Links
CAS Registry No. 222030-63-9
ChEMBL Ligand CHEMBL1206232
PubChem CID 5351387
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Comments
Fosbretabulin is dephophotylated to the tubulin polymerisation inhibitor combretastatin A4 [2]. The compound was originally isolated from the African bush willow (Combretum caffrum) [1,3].