MK-24

Ligand id: 8858

Name: MK-24

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 89.76
Molecular weight 481.27
XLogP 6.62
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(1R,3S,5Z)-5-[(2E)-2-[(7aS)-7a-methyl-1-[(2R)-4-(phenylsulfonimidoyl)butan-2-yl]-3a,5,6,7-tetrahydro-3H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Database Links
ChEMBL Ligand CHEMBL255088
PubChem CID 44445025
Search Google for chemical match using the InChIKey MVSUCZHCZRRVTM-RKGHGREQSA-N
Search Google for chemicals with the same backbone MVSUCZHCZRRVTM
Search UniChem for chemical match using the InChIKey MVSUCZHCZRRVTM-RKGHGREQSA-N
Search UniChem for chemicals with the same backbone MVSUCZHCZRRVTM
Comments
MK-24 was discovered as an inhibitor of CYP24A1 [1], a 1,25-dihydroxyvitamin D3 (calcitrol) metabolising enzyme.