PF-3758309

Ligand id: 8937

Name: PF-3758309

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 130.31
Molecular weight 490.23
XLogP 4.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide
Synonyms
compound 1 [PMID: 24432870] | example 114 [US8530652] [4] | PF-03758309 | PF3758309
Database Links
ChEMBL Ligand CHEMBL3128043
PubChem CID 25227462
Search Google for chemical match using the InChIKey AYCPARAPKDAOEN-LJQANCHMSA-N
Search Google for chemicals with the same backbone AYCPARAPKDAOEN
Search UniChem for chemical match using the InChIKey AYCPARAPKDAOEN-LJQANCHMSA-N
Search UniChem for chemicals with the same backbone AYCPARAPKDAOEN
SynPHARM 83160 (in complex with p21 (RAC1) activated kinase 1)
83169 (in complex with p21 (RAC1) activated kinase 6)
Comments
PF-3758309 is an inhibitor of the p21 protein (Cdc42/Rac)-activated kinase (PAK) kinases [2-3].