JNJ-42165279

Ligand id: 9012

Name: JNJ-42165279

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 66.93
Molecular weight 410.1
XLogP 2.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-(4-chloropyridin-3-yl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine-1-carboxamide
Synonyms
Example 1 [WO2011139951 A1] [3] | JNJ42165279
Database Links
PubChem CID 54576693
Search Google for chemical match using the InChIKey YWGYNGCRVZLMCS-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YWGYNGCRVZLMCS
Search UniChem for chemical match using the InChIKey YWGYNGCRVZLMCS-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YWGYNGCRVZLMCS
Comments
JNJ-42165279 is an investigational, covalent and selective inhibitor of fatty acid amide hydrolase (FAAH) [3]. Preclinical test findings are reported in [2], with the conclusion that the favourable ADME and pharmacodynamic profiles of JNJ-42165279 supported it being progressed to clinical trial.