PF-03463275

Ligand id: 9057

Name: PF-03463275

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 41.37
Molecular weight 376.15
XLogP 2.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide
Synonyms
compound 10 [PMID: 19410451] | KB-79869 | PF-3463275
Database Links
BindingDB Ligand 50293564
ChEMBL Ligand CHEMBL563251
PubChem CID 44156901
Search Google for chemical match using the InChIKey KYLOBHXXQOZRKK-YIONKMFJSA-N
Search Google for chemicals with the same backbone KYLOBHXXQOZRKK
Search UniChem for chemical match using the InChIKey KYLOBHXXQOZRKK-YIONKMFJSA-N
Search UniChem for chemicals with the same backbone KYLOBHXXQOZRKK
Comments
PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, the GlyT1 glycine transporter [1], developed for potential anti-schizophrenia activity.

This entry represents the parent molecule. Its hydrochloride salt has PubChem CID 91799199.