PF-03463275

Ligand id: 9057

Name: PF-03463275

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 41.37
Molecular weight 376.15
XLogP 2.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide
Synonyms
compound 10 [PMID: 19410451] | KB-79869 | PF-3463275
Comments
PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, the GlyT1 glycine transporter [1], developed for potential anti-schizophrenia activity.

This entry represents the parent molecule. Its hydrochloride salt has PubChem CID 91799199.
Database Links
BindingDB Ligand 50293564
ChEMBL Ligand CHEMBL563251
GtoPdb PubChem SID 315661142
PubChem CID 44156901
Search Google for chemical match using the InChIKey KYLOBHXXQOZRKK-YIONKMFJSA-N
Search Google for chemicals with the same backbone KYLOBHXXQOZRKK
Search UniChem for chemical match using the InChIKey KYLOBHXXQOZRKK-YIONKMFJSA-N
Search UniChem for chemicals with the same backbone KYLOBHXXQOZRKK